Our patient developed a squamous cell carcinoma in a scar from a previous craniotomy. When he presented there was an orange sized lesion on the top of his head. He was deemed too old to have resection with a flap covering the defect and instead had radiation. The radiation decreased the size of the tumor but left bone exposed and residual tumor which eroded into the cranium causing a subdural empyema.
you notice a defect in the skull
and a subdural empyema
The most common types of skin cancers are basal cell ca which constitute 70%, and cutaneous melanomas which constitute 10%. Of malignancies arising in scars, squamous cell carcinomas are the most common and often found in burn scars.
The etiology of cancers in scars is not fully understood but proliferation due to chronic inflammation and poor vascularization of the scar tissue resulting in impaired immunological defense are thought to be factors. . Genetic factors may also play a role with mutations in p53 and FAS genes being associated with cancer. These cancers also arise in scars in the lung. The presence of type III collagen and extracellular matrix suggest an ongoing fibrosing process secondary to host response to neoplasm. The high concentration oftype III collagen in scar carcinoma indicates that the fibrous tissue isin an active immature state compared with normal collagen which contains type I and type V collagen.
Our patient had been told he was not a candidate for surgery several months PTA , was treated for a UTI and sent back to the Veteran’s home on hospice.
Kowal-VernA, Criswell BK. Burn scar neoplasm: a literature review and statistical analysis. Burns. 2005;31:403-13.
Treves N, Pack GT The development of cancer in burn scars: an analysis and report of thirty-four cases. Surg Gynecol Obstst 1930;51:749-82.
O’Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. BrJ Cancer. 2001;85:473-83.
Bobba RK, Holly JS, Loy T, Perry M. Scar carcinoma of the lung: a historical perspective. 2011. Clinical Lung Cancer;vol 12: 148-154.